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Carol Addy Selected Research

N- (3- (4- chlorophenyl)- 2- (3- cyanophenyl)- 1- methylpropyl)- 2- methyl- 2- ((5- (trifluoromethyl)pyridin- 2- yl)oxy)propanamide

8/2012Human abuse potential and cognitive effects of taranabant, a cannabinoid 1 receptor inverse agonist: a randomized, double-blind, placebo- and active-controlled, crossover study in recreational polydrug users.
12/2010Development of a population pharmacokinetic model for taranabant, a cannibinoid-1 receptor inverse agonist.
10/2010Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans.
11/2008Influence of taranabant, a cannabinoid-1 receptor inverse agonist, on pharmacokinetics and pharmacodynamics of warfarin.
6/2008Multiple-dose pharmacokinetics, pharmacodynamics, and safety of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, in healthy male volunteers.
4/2008Safety, tolerability, pharmacokinetics, and pharmacodynamic properties of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, for the treatment of obesity: results from a double-blind, placebo-controlled, single oral dose study in healthy volunteers.
1/2008The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.

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Carol Addy Research Topics

Disease

10Obesity
01/2016 - 03/2003
4Type 2 Diabetes Mellitus (MODY)
01/2017 - 03/2005
3Weight Loss (Weight Reduction)
01/2008 - 10/2006
1Hypertriglyceridemia
08/2017
1Hypoglycemia (Reactive Hypoglycemia)
01/2017
1Body Weight (Weight, Body)
03/2016
1Parkinson Disease (Parkinson's Disease)
07/2009
1Abdominal Pain (Pain, Abdominal)
04/2008
1Vomiting
04/2008
1Headache (Headaches)
04/2008
1Dizziness (Lightheadedness)
04/2008
1Hiccup (Hiccups)
04/2008
1Nausea
04/2008
1Overweight
10/2006
1Endometrial Neoplasms (Endometrial Cancer)
03/2003

Drug/Important Bio-Agent (IBA)

7N- (3- (4- chlorophenyl)- 2- (3- cyanophenyl)- 1- methylpropyl)- 2- methyl- 2- ((5- (trifluoromethyl)pyridin- 2- yl)oxy)propanamideIBA
08/2012 - 01/2008
4CannabinoidsIBA
08/2012 - 01/2008
32- (2,5- difluorophenyl)- 5- (2- (methylsulfonyl)- 2,6- dihydropyrrolo(3,4- c)pyrazol- 5(4H)- yl)tetrahydro- 2H- pyran- 3- amineIBA
01/2017 - 01/2016
2neuropeptide Y5 receptorIBA
08/2007 - 10/2006
2trans- N- (1- (2- fluorophenyl)- 1h- pyrazol- 3- yl)- 1'- oxo- spiro(cyclohexane- 1,3'(1'H)- furo(3,4- C)pyridine)- 4- carboxamideIBA
08/2007 - 10/2006
2Hormones (Hormone)IBA
08/2007 - 03/2003
2LeptinIBA
03/2005 - 03/2003
1Sterol Regulatory Element Binding Protein 1IBA
08/2017
1TabletsIBA
01/2017
1Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA
03/2016
1Dipeptidyl-Peptidase IV InhibitorsIBA
03/2016
1N-Methylaspartate (NMDA)IBA
07/2009
14-methylbenzyl 3- fluoro- 4- ((pyrimidin- 2- ylamino)methyl)piperidine- 1- carboxylateIBA
07/2009
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
07/2009
1Warfarin (Coumadin)FDA LinkGeneric
11/2008
1Pharmaceutical PreparationsIBA
04/2008
1Neuropeptide YIBA
08/2007
1Orlistat (Xenical)FDA Link
08/2007
1sibutramine (Meridia)FDA Link
08/2007
1C-Reactive ProteinIBA
03/2005
1pegylated leptinIBA
03/2005
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2005
1Therapeutic UsesIBA
03/2005
1Interleukin-6 (Interleukin 6)IBA
03/2005
1recombinant methionyl human leptinIBA
03/2005
1CytokinesIBA
03/2005
1Interleukin-10 (Interleukin 10)IBA
03/2005
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
03/2005
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
03/2005
1Insulin-Like Growth Factor I (IGF-1)IBA
03/2003
1AdiponectinIBA
03/2003
1Insulin-Like Growth Factor Binding Protein 3IBA
03/2003
1Insulin-Like Growth Factor II (Somatomedin A)IBA
03/2003

Therapy/Procedure

1Therapeutics
01/2008